| 2492 | 4/10/21 3:00pm | Merchant Road Field 3 | Framingham Storm | 1 - 1 | Hopkinton B6 Academy Orange | |
| 2495 | Unscheduled | Fruit St. Turf Field 2A | Hopkinton B6 Academy Orange | - | Southboro crew | To be rescheduled |
| 2499 | 4/24/21 2:30pm | Mansfield Physical Therapy & Wellness Field - 1A | Mansfield Mansfield Hornets II | - | Hopkinton B6 Academy Orange | |
| 2500 | 5/1/21 2:30pm | Ellsworth-McAfee Field A | Northborough Knights | - | Hopkinton B6 Academy Orange | |
| 2504 | 5/8/21 2:30pm | Fruit St. Turf Field 2B | Hopkinton B6 Academy Orange | - | Attleboro Road Runners | |
| 2507 | 5/15/21 2:30pm | Fruit St. Turf Field 2B | Hopkinton B6 Academy Orange | - | Framingham Storm | |
| 2511 | 5/22/21 1:00pm | Trottier Middle School - Track Infield | Southboro crew | - | Hopkinton B6 Academy Orange | |
| 2514 | 5/29/21 10:00am | Fruit St. Turf Field 2A | Hopkinton B6 Academy Orange | - | Mansfield Mansfield Hornets II | |
| 2516 | 6/5/21 2:30pm | Fruit St. Turf Field 2A | Hopkinton B6 Academy Orange | - | Northborough Knights | |
| 2519 | 6/12/21 12:30pm | Poncin Hewitt | Attleboro Road Runners | - | Hopkinton B6 Academy Orange | |
